PittsburghV1, Main, Exploration, bibRecord, 005400

Hypertension and Obesity and the Risk of Kidney Cancer in 2 Large Cohorts of US Men and Women

Identifieur interne : 005400 ( Main/Exploration ); précédent : 005399; suivant : 005401

Hypertension and Obesity and the Risk of Kidney Cancer in 2 Large Cohorts of US Men and Women

Auteurs : Kristen M. Sanfilippo [États-Unis] ; Kathleen M. Mctigue [États-Unis] ; Christian J. Fidler [États-Unis] ; James D. Neaton [États-Unis] ; YUEFANG CHANG [États-Unis] ; Linda F. Fried [États-Unis] ; SIMIN LIU [États-Unis] ; Lewis H. Kuller [États-Unis]

Source :

Hypertension : (Dallas, Tex. 1979) [ 0194-911X ] ; 2014.

RBID : Pascal:14-0124708

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Comorbidité, Facteurs de risque, Femelle, Humains, Hypertension artérielle (), Hypertension artérielle (physiopathologie), Hypertension artérielle (épidémiologie), Incidence, Indice de masse corporelle, Modèles de hasards proportionnels, Mâle, Obésité (), Obésité (physiopathologie), Obésité (épidémiologie), Pression sanguine (physiologie), Taux de survie, Tumeurs du rein (mortalité), Tumeurs du rein (épidémiologie), Valeur prédictive des tests, États-Unis d'Amérique, Études de cohortes, Études de suivi, Études longitudinales.
MESH :
- mortalité : Tumeurs du rein.
- physiologie : Pression sanguine.
- physiopathologie : Hypertension artérielle, Obésité.
- épidémiologie : Hypertension artérielle, Obésité, Tumeurs du rein.
Pascal (Inist)
- Adulte, Adulte d'âge moyen, Comorbidité, Facteurs de risque, Femelle, Humains, Hypertension artérielle, Incidence, Indice de masse corporelle, Modèles de hasards proportionnels, Mâle, Obésité, Cancer rein, Pathologie de l'appareil circulatoire, Facteur risque, Risque, Etats-Unis, Etude cohorte, Santé publique, Sexe, Femme, Mâle, Femelle, Pression sanguine, Pression artérielle, Poids corporel, Epidémiologie, Rein, Appareil circulatoire, Cardiologie, Etat nutritionnel, Taux de survie, Valeur prédictive des tests, États-Unis d'Amérique, Études de cohortes, Études de suivi, Études longitudinales.
Wicri :
- geographic : États-Unis.
- topic : Santé publique, Femme.

English descriptors

KwdEn :
- Adult, Arterial pressure, Blood Pressure (physiology), Blood pressure, Body Mass Index, Body weight, Cardiology, Cardiovascular disease, Circulatory system, Cohort Studies, Cohort study, Comorbidity, Epidemiology, Female, Follow-Up Studies, Humans, Hypertension, Hypertension (complications), Hypertension (epidemiology), Hypertension (physiopathology), Incidence, Kidney, Kidney Neoplasms (epidemiology), Kidney Neoplasms (mortality), Kidney cancer, Longitudinal Studies, Male, Middle Aged, Nutritional status, Obesity, Obesity (complications), Obesity (epidemiology), Obesity (physiopathology), Predictive Value of Tests, Proportional Hazards Models, Public health, Risk, Risk Factors, Risk factor, Sex, Survival Rate, United States, Woman.
MESH :
- geographic : United States.
- complications : Hypertension, Obesity.
- epidemiology : Hypertension, Kidney Neoplasms, Obesity.
- mortality : Kidney Neoplasms.
- physiology : Blood Pressure.
- physiopathology : Hypertension, Obesity.
- Adult, Body Mass Index, Cohort Studies, Comorbidity, Female, Follow-Up Studies, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Proportional Hazards Models, Risk Factors, Survival Rate.

Abstract

Kidney cancer incidence is increasing globally. Reasons for this rise are unclear but could relate to obesity and hypertension. We analyzed longitudinal relationships between hypertension and obesity and kidney cancer incidence in 156 774 participants of the Women's Health Initiative clinical trials and observational studies over 10.8 years. In addition, we examined the effect of blood pressure (BP) on kidney cancer deaths for over 25 years among the 353 340 men screened for the Multiple Risk Factor Intervention Trial (MRFIT). In the Women's Health Initiative, systolic BP (SBP) was categorized in 6 groups from <120 to >160 mmHg, and body mass index was categorized using standard criteria. In age-adjusted analyses, kidney cancer risk increased across SBP categories (P value for trend <0.0001) and body mass index categories (P value for trend <0.0001). In adjusted Cox proportional hazards models, both SBP levels and body mass index were predictors of kidney cancer. In the MRFIT sample, there were 906 deaths after an average of 25 years of follow-up attributed to kidney cancer among the 353 340 participants aged 35 to 57 years at screening. The risk of death from kidney cancer increased in a dose-response fashion with increasing SBP (hazard ratio, 1.87 for SBP>160 versus <120 mmHg; 95% confidence interval, 1.38-2.53). Risk was increased among cigarette smokers. Further research is needed to determine the pathophysiologic basis of relationships between both higher BP and the risk of kidney cancer, and whether specific drug therapies for hypertension can reduce kidney cancer risk.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098147

Affiliations:

Le document en format XML

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<series><title level="j" type="main">Hypertension : (Dallas, Tex. 1979)</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Arterial pressure</term>
<term>Blood Pressure (physiology)</term>
<term>Blood pressure</term>
<term>Body Mass Index</term>
<term>Body weight</term>
<term>Cardiology</term>
<term>Cardiovascular disease</term>
<term>Circulatory system</term>
<term>Cohort Studies</term>
<term>Cohort study</term>
<term>Comorbidity</term>
<term>Epidemiology</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Hypertension</term>
<term>Hypertension (complications)</term>
<term>Hypertension (epidemiology)</term>
<term>Hypertension (physiopathology)</term>
<term>Incidence</term>
<term>Kidney</term>
<term>Kidney Neoplasms (epidemiology)</term>
<term>Kidney Neoplasms (mortality)</term>
<term>Kidney cancer</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nutritional status</term>
<term>Obesity</term>
<term>Obesity (complications)</term>
<term>Obesity (epidemiology)</term>
<term>Obesity (physiopathology)</term>
<term>Predictive Value of Tests</term>
<term>Proportional Hazards Models</term>
<term>Public health</term>
<term>Risk</term>
<term>Risk Factors</term>
<term>Risk factor</term>
<term>Sex</term>
<term>Survival Rate</term>
<term>United States</term>
<term>Woman</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Comorbidité</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hypertension artérielle ()</term>
<term>Hypertension artérielle (physiopathologie)</term>
<term>Hypertension artérielle (épidémiologie)</term>
<term>Incidence</term>
<term>Indice de masse corporelle</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Obésité ()</term>
<term>Obésité (physiopathologie)</term>
<term>Obésité (épidémiologie)</term>
<term>Pression sanguine (physiologie)</term>
<term>Taux de survie</term>
<term>Tumeurs du rein (mortalité)</term>
<term>Tumeurs du rein (épidémiologie)</term>
<term>Valeur prédictive des tests</term>
<term>États-Unis d'Amérique</term>
<term>Études de cohortes</term>
<term>Études de suivi</term>
<term>Études longitudinales</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>United States</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hypertension</term>
<term>Obesity</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hypertension</term>
<term>Kidney Neoplasms</term>
<term>Obesity</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Kidney Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Tumeurs du rein</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Pression sanguine</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Hypertension artérielle</term>
<term>Obésité</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypertension</term>
<term>Obesity</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Hypertension artérielle</term>
<term>Obésité</term>
<term>Tumeurs du rein</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Body Mass Index</term>
<term>Cohort Studies</term>
<term>Comorbidity</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Incidence</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Predictive Value of Tests</term>
<term>Proportional Hazards Models</term>
<term>Risk Factors</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Comorbidité</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hypertension artérielle</term>
<term>Incidence</term>
<term>Indice de masse corporelle</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Obésité</term>
<term>Cancer rein</term>
<term>Pathologie de l'appareil circulatoire</term>
<term>Facteur risque</term>
<term>Risque</term>
<term>Etats-Unis</term>
<term>Etude cohorte</term>
<term>Santé publique</term>
<term>Sexe</term>
<term>Femme</term>
<term>Mâle</term>
<term>Femelle</term>
<term>Pression sanguine</term>
<term>Pression artérielle</term>
<term>Poids corporel</term>
<term>Epidémiologie</term>
<term>Rein</term>
<term>Appareil circulatoire</term>
<term>Cardiologie</term>
<term>Etat nutritionnel</term>
<term>Taux de survie</term>
<term>Valeur prédictive des tests</term>
<term>États-Unis d'Amérique</term>
<term>Études de cohortes</term>
<term>Études de suivi</term>
<term>Études longitudinales</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Santé publique</term>
<term>Femme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Kidney cancer incidence is increasing globally. Reasons for this rise are unclear but could relate to obesity and hypertension. We analyzed longitudinal relationships between hypertension and obesity and kidney cancer incidence in 156 774 participants of the Women's Health Initiative clinical trials and observational studies over 10.8 years. In addition, we examined the effect of blood pressure (BP) on kidney cancer deaths for over 25 years among the 353 340 men screened for the Multiple Risk Factor Intervention Trial (MRFIT). In the Women's Health Initiative, systolic BP (SBP) was categorized in 6 groups from <120 to >160 mmHg, and body mass index was categorized using standard criteria. In age-adjusted analyses, kidney cancer risk increased across SBP categories (P value for trend <0.0001) and body mass index categories (P value for trend <0.0001). In adjusted Cox proportional hazards models, both SBP levels and body mass index were predictors of kidney cancer. In the MRFIT sample, there were 906 deaths after an average of 25 years of follow-up attributed to kidney cancer among the 353 340 participants aged 35 to 57 years at screening. The risk of death from kidney cancer increased in a dose-response fashion with increasing SBP (hazard ratio, 1.87 for SBP>160 versus <120 mmHg; 95% confidence interval, 1.38-2.53). Risk was increased among cigarette smokers. Further research is needed to determine the pathophysiologic basis of relationships between both higher BP and the risk of kidney cancer, and whether specific drug therapies for hypertension can reduce kidney cancer risk.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
<li>Rhode Island</li>
</region>
<settlement><li>Pittsburgh</li>
<li>Providence (Rhode Island)</li>
</settlement>
<orgName><li>Université Brown</li>
<li>Université de Pittsburgh</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Sanfilippo, Kristen M" sort="Sanfilippo, Kristen M" uniqKey="Sanfilippo K" first="Kristen M." last="Sanfilippo">Kristen M. Sanfilippo</name>
</noRegion>
<name sortKey="Fidler, Christian J" sort="Fidler, Christian J" uniqKey="Fidler C" first="Christian J." last="Fidler">Christian J. Fidler</name>
<name sortKey="Fried, Linda F" sort="Fried, Linda F" uniqKey="Fried L" first="Linda F." last="Fried">Linda F. Fried</name>
<name sortKey="Fried, Linda F" sort="Fried, Linda F" uniqKey="Fried L" first="Linda F." last="Fried">Linda F. Fried</name>
<name sortKey="Fried, Linda F" sort="Fried, Linda F" uniqKey="Fried L" first="Linda F." last="Fried">Linda F. Fried</name>
<name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H." last="Kuller">Lewis H. Kuller</name>
<name sortKey="Mctigue, Kathleen M" sort="Mctigue, Kathleen M" uniqKey="Mctigue K" first="Kathleen M." last="Mctigue">Kathleen M. Mctigue</name>
<name sortKey="Mctigue, Kathleen M" sort="Mctigue, Kathleen M" uniqKey="Mctigue K" first="Kathleen M." last="Mctigue">Kathleen M. Mctigue</name>
<name sortKey="Neaton, James D" sort="Neaton, James D" uniqKey="Neaton J" first="James D." last="Neaton">James D. Neaton</name>
<name sortKey="Sanfilippo, Kristen M" sort="Sanfilippo, Kristen M" uniqKey="Sanfilippo K" first="Kristen M." last="Sanfilippo">Kristen M. Sanfilippo</name>
<name sortKey="Simin Liu" sort="Simin Liu" uniqKey="Simin Liu" last="Simin Liu">SIMIN LIU</name>
<name sortKey="Yuefang Chang" sort="Yuefang Chang" uniqKey="Yuefang Chang" last="Yuefang Chang">YUEFANG CHANG</name>
</country>
</tree>
</affiliations>
</record>

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Hypertension and Obesity and the Risk of Kidney Cancer in 2 Large Cohorts of US Men and Women

Hypertension and Obesity and the Risk of Kidney Cancer in 2 Large Cohorts of US Men and Women

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